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KMID : 0816119990020020233
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Korean Journal of Pediatric Gastroenterolology and Nutrition
1999 Volume.2 No. 2 p.233 ~ p.239
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A Case of Acrodermatitis Enteropathica Associated with CMV Hepatitis
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Kim Kwang-Yeol
Park Jae-Ock
Shin Sang-Mann
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Abstract
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Acrodermatitis enteropethica (AE) is a rare autosomal recessive disorder of zinc
absorption leading to chronic diarrhea and characteristic skin lesion. The term is also
applied to any acquired zinc deficiency state resulting in the same clinical pictures. We
experienced one case of AE in 1 month old male infant who had bacterial enterocolitis.
The skin around mouth, anus, eyes, ears, hands and legs became reddish, vesicular and
eczematoid. Serum zinc level was decreased to 51.4 ㎍/dL (N=70∼150). Endoscopic
finding revealed pale gastric mucosa and villous atrophy of small intestine. Biopsy
finding of small intestine showed no villi due to mucosal atrophy. On 13 day of
admission jaundice with DIC were noted and AST & ALT were elevated to 110 & 36.8
IU/L, respectively. Diarrhea was improved but jaundice and liver function were not
recovered until discharge from hospital. After discharge when the patient was 4 months
of age serum bilirubin and AST&ALT had not been normalized. CMV shell vial culture
of urine and CMV Ig G antibody were positive. So intravenous ganciclovir injection of
7.5 ㎎/㎏, two times a day for 2 weeks and then 10 ㎎/㎏/day for 3 months was done
from 4 to 6 months of age. No virus was found in the urine and AST & ALT were
normalized at 2 months after stopping ganciclovir treatment.
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KEYWORD
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Acrodermatitis enteropathica, CMV Hepatitis,
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